Title : The pathogenic S688Y mutation in the ligand-binding domain of the GluN1 subunit regulates the properties of NMDA receptors.

Pub. Date : 2020 Oct 29

PMID : 33122756






3 Functional Relationships(s)
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1 We found that the S688Y mutation significantly increases the EC50 of both glycine and D-serine in GluN1/GluN2A and GluN1/GluN2B receptors, and significantly slows desensitisation of GluN1/GluN3A receptors. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens
2 We found that the S688Y mutation significantly increases the EC50 of both glycine and D-serine in GluN1/GluN2A and GluN1/GluN2B receptors, and significantly slows desensitisation of GluN1/GluN3A receptors. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens
3 We found that the S688Y mutation significantly increases the EC50 of both glycine and D-serine in GluN1/GluN2A and GluN1/GluN2B receptors, and significantly slows desensitisation of GluN1/GluN3A receptors. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens