Pub. Date : 2020 Dec 25
PMID : 33115754
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Therapeutic targeting of pancreatic cancer stem cells by dexamethasone modulation of the MKP-1-JNK axis. | Dexamethasone | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Using in vitro models of CSCs and in vivo models of tumor initiation in which CSCs give rise to xenograft tumors, we show that dexamethasone induces expression of MKP-1, a MAPK phosphatase, via glucocorticoid receptor activation, thereby inactivating JNK, which is required for self-renewal and tumor-initiation by pancreatic CSCs as well as for their expression of survivin, an anti-apoptotic protein implicated in multi-drug resistance. | Dexamethasone | mitogen-activated protein kinase 8 | Homo sapiens |