Title : Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3.

Pub. Date : 2020 Oct 26

PMID : 33114754






2 Functional Relationships(s)
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1 The crystal structure of CLK1 in complex with CAF052, one of the most potent inhibitors identified for ERK3, revealed typical type-I binding mode of the inhibitor, which by structural comparison could likely be maintained in ERK3. caf052 mitogen-activated protein kinase 6 Homo sapiens
2 The crystal structure of CLK1 in complex with CAF052, one of the most potent inhibitors identified for ERK3, revealed typical type-I binding mode of the inhibitor, which by structural comparison could likely be maintained in ERK3. caf052 mitogen-activated protein kinase 6 Homo sapiens