Title : Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress.

Pub. Date : 2021 Jan

PMID : 33109619






1 Functional Relationships(s)
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1 These studies provide mechanistic information on a novel chemical scaffold that selectively regulates ERK1/2-targeted transcription factors and inhibits the proliferation of A375 melanoma cells through a ROS-dependent mechanism. Reactive Oxygen Species mitogen-activated protein kinase 3 Homo sapiens