Pub. Date : 2020 Dec 1
PMID : 33103444
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we demonstrated that cisplatin activates AMPK (Thr172 phosphorylation) in cultured renal tubular epithelial cells in a time-dependent manner, which is associated with p53 phosphorylation. | Cisplatin | transformation related protein 53, pseudogene | Mus musculus |
| 2 | Compound C, a selective AMPK inhibitor, suppressed cisplatin-induced AMPK activation, p53 phosphorylation, Bax induction and caspase 3 activation. | Cisplatin | transformation related protein 53, pseudogene | Mus musculus |
| 3 | Furthermore, silencing AMPK expression by siRNA attenuated cisplatin-induced p53 phosphorylation, Bax induction, and caspase 3 activation. | Cisplatin | transformation related protein 53, pseudogene | Mus musculus |
| 4 | In a mouse model of cisplatin-induced kidney injury, compound C inhibited p53 phosphorylation, Bax expression, caspase 3 activation, and apoptosis, protecting the kidney from injury and dysfunction. | Cisplatin | transformation related protein 53, pseudogene | Mus musculus |
| 5 | Taken together, these results suggest that AMPK-p53-Bax signaling pathway plays a crucial role in cisplatin-induced tubular epithelial cell apoptosis. | Cisplatin | transformation related protein 53, pseudogene | Mus musculus |