Title : New cyanopyridine-based scaffold as PIM-1 inhibitors and apoptotic inducers: Synthesis and SARs study.

Pub. Date : 2020 Dec

PMID : 33099167






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Based on cytotoxicity results via MTT assay against prostate carcinoma PC3, human hepatocellular carcinoma HepG2 and breast adenocarcinoma MCF-7 cell lines, the most potent cytotoxic cyanopyridine hits, 6, 7, 8, 12 and 13 were 1.5-3.3 times more inhibitor of cell proliferation than the reference standard, 5-FU. monooxyethylene trimethylolpropane tristearate proprotein convertase subtilisin/kexin type 1 Homo sapiens