Pub. Date : 2021 Jan 15
PMID : 33096358
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Furthermore, curcumin significantly increased the nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) and consequently upregulated the expression of heme oxygenase 1 (HO-1) under HgCl2 treatment. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Furthermore, curcumin significantly increased the nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) and consequently upregulated the expression of heme oxygenase 1 (HO-1) under HgCl2 treatment. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | In conclusion, our data identify that curcumin could enhance Nrf2-mediated HO-1 to upregulate antioxidant ability, which might be associate with CYP450 signaling to suppress liver damage induced by HgCl2. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 5 | The present study further enriches and perfects the mechanism theory of HgCl2 toxicity and suggest that the CYP450 signaling and Nrf2/HO-1 pathway is important in shedding light on curcumin"s hepatoprotective effects in HgCl2 toxicity. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |