Pub. Date : 2020 Oct 22
PMID : 33093598
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study was to characterize the population pharmacokinetics of levodopa following LECIG and levodopa-carbidopa intestinal gel (LCIG) infusion to investigate suitable translation of dose from LCIG to LECIG treatment, and the impact of common variations in the dopa-decarboxylase (DDC) and catechol-O-methyltransferase (COMT) genes on levodopa pharmacokinetics. | Levodopa | catechol-O-methyltransferase | Homo sapiens |
| 2 | The aim of this study was to characterize the population pharmacokinetics of levodopa following LECIG and levodopa-carbidopa intestinal gel (LCIG) infusion to investigate suitable translation of dose from LCIG to LECIG treatment, and the impact of common variations in the dopa-decarboxylase (DDC) and catechol-O-methyltransferase (COMT) genes on levodopa pharmacokinetics. | Levodopa | catechol-O-methyltransferase | Homo sapiens |
| 3 | The individuals with higher DDC and COMT enzyme activity showed tendencies towards higher levodopa CL/F. | Levodopa | catechol-O-methyltransferase | Homo sapiens |