Title : Synthesis of 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitors: Selectivity, metabolic stability and enhanced potency.

Pub. Date : 2021 Jan 1

PMID : 33081987






2 Functional Relationships(s)
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1 After we identified the androsterone (ADT) derivative 1 as a first steroidal inhibitor of 17beta-HSD10, new analogs were synthesized to increase the metabolic stability, to improve the selectivity of inhibition over 17beta-HSD3 and to optimize the inhibitory potency. Androsterone hydroxysteroid 17-beta dehydrogenase 3 Homo sapiens
2 After we identified the androsterone (ADT) derivative 1 as a first steroidal inhibitor of 17beta-HSD10, new analogs were synthesized to increase the metabolic stability, to improve the selectivity of inhibition over 17beta-HSD3 and to optimize the inhibitory potency. Androsterone hydroxysteroid 17-beta dehydrogenase 3 Homo sapiens