Pub. Date : 2020 Oct 16
PMID : 33081375
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suppression of the Rho-family GTPase Rac1, which is under the negative control of ROCK, with expression of the dominant negative Rac1 mutant (Rac1N17) prevented Y-27632-induced neurite outgrowth. | Y 27632 | Rac family small GTPase 1 | Rattus norvegicus |
| 2 | Suppression of the Rho-family GTPase Rac1, which is under the negative control of ROCK, with expression of the dominant negative Rac1 mutant (Rac1N17) prevented Y-27632-induced neurite outgrowth. | Y 27632 | Rac family small GTPase 1 | Rattus norvegicus |
| 3 | Moreover, the Rac1 inhibitor NSC23766 prevented Y-27632-induced AKT and p21-activated kinase 1 (PAK1) activation. | Y 27632 | Rac family small GTPase 1 | Rattus norvegicus |
| 4 | In conclusion, our results suggest that Rac1/NOX1-dependent ROS generation and subsequent activation of the AKT/PAK1 cascade contribute to Y-27632-induced neurite outgrowth in PC12 cells. | Y 27632 | Rac family small GTPase 1 | Rattus norvegicus |