Pub. Date : 2020 Oct 16
PMID : 33081092
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In our study, we investigated the MEK inhibitor selumetinib and PI3K/mTOR dual inhibitor BEZ235 alone and in combination in BRAF-only mutant and BRAF + PI3K/PTEN double mutant cancer cells using short- and long-term 2D viability assays, spheroid assays, and immunoblots. | AZD 6244 | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |
| 2 | In the 2D assays, selumetinib was more effective on BRAF-only mutant lines when compared to BRAF + PI3K/PTEN double mutants. | AZD 6244 | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |