Title : mTOR Inhibition Ablates Cisplatin-Resistant Salivary Gland Cancer Stem Cells.

Pub. Date : 2021 Apr

PMID : 33073679






3 Functional Relationships(s)
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1 The purpose of this study was to investigate the effect of therapeutic inhibition of mTOR (mechanistic target of rapamycin) on resistance of CSCs to cisplatin, a prototypic platinum-based chemotherapeutic agent. Platinum mechanistic target of rapamycin kinase Homo sapiens
2 The purpose of this study was to investigate the effect of therapeutic inhibition of mTOR (mechanistic target of rapamycin) on resistance of CSCs to cisplatin, a prototypic platinum-based chemotherapeutic agent. Platinum mechanistic target of rapamycin kinase Homo sapiens
3 Collectively, these results demonstrate that therapeutic inhibition of mTOR ablates cytotoxic-resistant CSCs, and they suggest that a combination of an mTOR inhibitor and platinum-based chemotherapy might be beneficial to patients with salivary gland mucoepidermoid carcinoma. Platinum mechanistic target of rapamycin kinase Homo sapiens