Title : Targeting miR-124/Ferroportin signaling ameliorated neuronal cell death through inhibiting apoptosis and ferroptosis in aged intracerebral hemorrhage murine model.

Pub. Date : 2020 Nov

PMID : 33068460






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Ferroportin1 (Fpn) is the only identified nonheme iron exporter in mammals to date. Iron solute carrier family 40 (iron-regulated transporter), member 1 Mus musculus
2 Ferroportin1 (Fpn) is the only identified nonheme iron exporter in mammals to date. Iron solute carrier family 40 (iron-regulated transporter), member 1 Mus musculus
3 Fpn deficiency induced by injecting an adeno-associated virus (AAV) overexpressing cre recombinase into aged Fpn-floxed mice significantly worsened the symptoms post-ICH, including hematoma volume, cell apoptosis, iron accumulation, and neurologic dysfunction. Iron solute carrier family 40 (iron-regulated transporter), member 1 Mus musculus
4 Our study demonstrated the critical role of miR-124/Fpn signaling in iron metabolism and neuronal death post-ICH in aged murine model. Iron solute carrier family 40 (iron-regulated transporter), member 1 Mus musculus