Title : Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide.

Pub. Date : 2020 Oct 30

PMID : 33063092






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 It conserves NAD+ and prevents ATP depletion by PARP 1 and Sirtuin 1 (silent mating type information regulation 2 homologue 1) inhibition, enhances NAD+ synthesis, and hence that of NADP+ which is a stronger PARP inhibitor, reverses lung injury caused by ischaemia/reperfusion, inhibits proinflammatory cytokines and is effective against HIV infection. Adenosine Triphosphate sirtuin 1 Homo sapiens