Title : Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells.

Pub. Date : 2021 Feb 15

PMID : 33053467






1 Functional Relationships(s)
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1 HUVECs exposed with SiO2 NPs generate excess amount of reactive oxygen species (ROS) and lactate dehydrogenase (LDH), together with the up-regulation of cell inflammatory factors [interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), tumor necrotic factor-alpha (TNF-alpha)] and cell adhesion molecules [intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1)]. Silicon Dioxide interleukin 1 alpha Homo sapiens