Pub. Date : 2020
PMID : 33052306
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the presence of nicotine, INS1 and sACE2 showed a reduced binding affinity score of -12.6 kcal/mol (Vs -15.7 kcal/mol without nicotine), and a lowered interface area of 1933.6 A2 (Vs 2057.3A2 without nicotine). | Nicotine | forkhead box M1 | Homo sapiens |
| 2 | In the presence of nicotine, INS1 and sACE2 showed a reduced binding affinity score of -12.6 kcal/mol (Vs -15.7 kcal/mol without nicotine), and a lowered interface area of 1933.6 A2 (Vs 2057.3A2 without nicotine). | Nicotine | forkhead box M1 | Homo sapiens |
| 3 | In the presence of nicotine, INS1 and sACE2 showed a reduced binding affinity score of -12.6 kcal/mol (Vs -15.7 kcal/mol without nicotine), and a lowered interface area of 1933.6 A2 (Vs 2057.3A2 without nicotine). | Nicotine | forkhead box M1 | Homo sapiens |
| 4 | However, nicotine showed a higher binding affinity score of -6.33 kcal/mol for the sACE2-INS1 complex than the sACE2 alone with -5.24 kcal/mol. | Nicotine | forkhead box M1 | Homo sapiens |
| 5 | A lowered inhibitory constant value of 22.95microM recorded while nicotine interacted with the sACE2-INS1 complex over the sACE2 alone with 151.69 microM. | Nicotine | forkhead box M1 | Homo sapiens |
| 6 | In summary, nicotine showed a profound binding affinity for the sACE2-INS1 complex than the sACE2 alone paving for the clinical trials to validate its therapeutic efficacy as a bitter compound against the SARS-CoV-2 virulence. | Nicotine | forkhead box M1 | Homo sapiens |