PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33052306-5	2020	In the presence of nicotine, INS1 and sACE2 showed a reduced binding affinity score of -12.6 kcal/mol (Vs -15.7 kcal/mol without nicotine), and a lowered interface area of 1933.6 A2 (Vs 2057.3A2 without nicotine).	Nicotine	19-27	forkhead box M1	Homo sapiens	29-33	
33052306-5	2020	In the presence of nicotine, INS1 and sACE2 showed a reduced binding affinity score of -12.6 kcal/mol (Vs -15.7 kcal/mol without nicotine), and a lowered interface area of 1933.6 A2 (Vs 2057.3A2 without nicotine).	Nicotine	129-137	forkhead box M1	Homo sapiens	29-33	
33052306-5	2020	In the presence of nicotine, INS1 and sACE2 showed a reduced binding affinity score of -12.6 kcal/mol (Vs -15.7 kcal/mol without nicotine), and a lowered interface area of 1933.6 A2 (Vs 2057.3A2 without nicotine).	Nicotine	129-137	forkhead box M1	Homo sapiens	29-33	
33052306-8	2020	However, nicotine showed a higher binding affinity score of -6.33 kcal/mol for the sACE2-INS1 complex than the sACE2 alone with -5.24 kcal/mol.	Nicotine	9-17	forkhead box M1	Homo sapiens	89-93	
33052306-9	2020	A lowered inhibitory constant value of 22.95microM recorded while nicotine interacted with the sACE2-INS1 complex over the sACE2 alone with 151.69 microM.	Nicotine	66-74	forkhead box M1	Homo sapiens	101-105	
33052306-10	2020	In summary, nicotine showed a profound binding affinity for the sACE2-INS1 complex than the sACE2 alone paving for the clinical trials to validate its therapeutic efficacy as a bitter compound against the SARS-CoV-2 virulence.	Nicotine	12-20	forkhead box M1	Homo sapiens	70-74