Title : Dexamethasone Inhibits TRAIL-Induced Apoptosis through c-FLIP(L) Upregulation and DR5 Downregulation by GSK3β Activation in Cancer Cells.

Pub. Date : 2020 Oct 9

PMID : 33050333






2 Functional Relationships(s)
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1 In addition, DEX decreased protein stability of DR5 via GSK-3beta-mediated upregulation of Cbl, an E3 ligase of DR5. Dexamethasone Cbl proto-oncogene Homo sapiens
2 Knockdown of Cbl by siRNA markedly inhibited DEX-induced DR5 downregulation. Dexamethasone Cbl proto-oncogene Homo sapiens