Pub. Date : 2021 Mar
PMID : 33045408
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | At concentrations <= 2.5 mM, metformin significantly increased oxygen consumption rate (OCR) in the hiPSC-CMs by activating AMPK-dependent signaling and enhancing mitochondrial biogenesis. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | Thus, in human heart, metformin might improve cardioprotection due to its biphasic effect on mitochondria: at low concentrations, it activates mitochondrial biogenesis via AMPK signaling and increases the OCR; at high concentrations, it inhibits the respiration by directly affecting the activity of complex I, reduces oxidative stress and delays mPTP formation. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |