Title : Anionic phospholipid expression as a molecular target in Listeria monocytogenes and Escherichia coli.

Pub. Date : 2020 Dec

PMID : 33045345






4 Functional Relationships(s)
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1 Results presented here suggest that this ANXA5-ampicillin bioconjugate participates in a positive feedback loop where anionic phospholipid, the target of the delivery vehicle ANXA5, is upregulated by the chemotherapeutic payload of the bioconjugate. Ampicillin annexin A5 Homo sapiens
2 Results presented here suggest that this ANXA5-ampicillin bioconjugate participates in a positive feedback loop where anionic phospholipid, the target of the delivery vehicle ANXA5, is upregulated by the chemotherapeutic payload of the bioconjugate. Ampicillin annexin A5 Homo sapiens
3 As measured by the IC50, conjugation to ANXA5 resulted in increasing the antibiotic activity of ampicillin against L. monocytogenes and E. coli by more than 4 and 3 orders of magnitude, respectively, compared to free ampicillin, while activity of moxifloxacin against L. monocytogenes is increased by 4 orders of magnitude. Ampicillin annexin A5 Homo sapiens
4 As measured by the IC50, conjugation to ANXA5 resulted in increasing the antibiotic activity of ampicillin against L. monocytogenes and E. coli by more than 4 and 3 orders of magnitude, respectively, compared to free ampicillin, while activity of moxifloxacin against L. monocytogenes is increased by 4 orders of magnitude. Ampicillin annexin A5 Homo sapiens