Pub. Date : 2021 Jun
PMID : 33038289
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both studies confirmed longer half-lives for active metabolites and lower peak-to-trough fluctuations for the sum of the metabolites (total [alpha+beta]-HTBZ) following deutetrabenazine compared with tetrabenazine (3- to 4-fold and 11-fold, respectively) in steady-state conditions. | Tetrabenazine | amyloid beta precursor protein | Homo sapiens |
| 2 | Deutetrabenazine doses estimated to provide total (alpha+beta)-HTBZ exposure comparable to tetrabenazine 25 mg were 11.4-13.2 mg. Food had no effect on exposure to total (alpha+beta)-HTBZ, as measured by AUC. | Tetrabenazine | amyloid beta precursor protein | Homo sapiens |
| 3 | Although the total (alpha+beta)-HTBZ Cmax of deutetrabenazine was increased by 50% in the presence of food, it remained lower than that of tetrabenazine. | Tetrabenazine | amyloid beta precursor protein | Homo sapiens |