Title : Activation of forkhead box O3a by mono(2-ethylhexyl)phthalate and its role in protection against mono(2-ethylhexyl)phthalate-induced oxidative stress and apoptosis in human cardiomyocytes.

Pub. Date : 2021 Apr

PMID : 33029813






5 Functional Relationships(s)
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1 The expression of FOXO3a and its target genes, mitochondrial superoxide dismutase (Mn-SOD) and apoptosis repressor with caspase recruitment domain (ARC), increased after MEHP exposure, but the expression of p-FOXO3a protein was decreased. mono-(2-ethylhexyl)phthalate superoxide dismutase 2 Homo sapiens
2 The expression of FOXO3a and its target genes, mitochondrial superoxide dismutase (Mn-SOD) and apoptosis repressor with caspase recruitment domain (ARC), increased after MEHP exposure, but the expression of p-FOXO3a protein was decreased. mono-(2-ethylhexyl)phthalate superoxide dismutase 2 Homo sapiens
3 Overexpression of FOXO3a decreased the production of ROS and the apoptosis rate induced by MEHP, and the expression of Mn-SOD and ARC was further increased after MEHP exposure. mono-(2-ethylhexyl)phthalate superoxide dismutase 2 Homo sapiens
4 In contrast, knockdown of FOXO3a resulted in increased ROS production and apoptosis and suppressed the expression of Mn-SOD and ARC in the presence of MEHP. mono-(2-ethylhexyl)phthalate superoxide dismutase 2 Homo sapiens
5 Activation of FOXO3a defends against MEHP-induced oxidative stress and apoptosis by upregulating the expression of Mn-SOD and ARC in AC16 cardiomyocytes. mono-(2-ethylhexyl)phthalate superoxide dismutase 2 Homo sapiens