Title : Characterization of a PERK Kinase Inhibitor with Anti-Myeloma Activity.

Pub. Date : 2020 Oct 5

PMID : 33028016






1 Functional Relationships(s)
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1 Here, we have used GSK2606414, an ATP-competitive potent PERK inhibitor, and found significant anti-proliferative and apoptotic effects in a panel of MM cell lines. 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens