Title : Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.

Pub. Date : 2020 Oct 20

PMID : 33020270






1 Functional Relationships(s)
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1 Importantly, combining olaparib with NU7441, a DNA-PKcs inhibitor that blocks NHEJ in HCC, synergistically suppressed HCC growth in both mice and HCC patient-derived-xenograft models. 8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one protein kinase, DNA activated, catalytic polypeptide Mus musculus