Title : Cell Type-Specific Roles of CD38 in the Interactions of Isoniazid with NAD+ in the Liver.

Pub. Date : 2020 Dec

PMID : 33020065






5 Functional Relationships(s)
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1 Cell type-specific roles of CD38 in the interactions of isoniazid with NAD+ in the liver. NAD CD38 antigen Mus musculus
2 Our previous work revealed the CD38-dependent interactions of isoniazid (INH), an anti-tuberculosis drug, with NAD+ to form INH-NAD adduct. NAD CD38 antigen Mus musculus
3 Our previous work revealed the CD38-dependent interactions of isoniazid (INH), an anti-tuberculosis drug, with NAD+ to form INH-NAD adduct. NAD CD38 antigen Mus musculus
4 These data suggest that hepatic non-parenchymal cells, such as KC and HSC, are the major cell types responsible for the CD38-dependent interactions of INH with NAD+ in the liver. NAD CD38 antigen Mus musculus
5 Our work also revealed the essential roles of non-parenchymal cells including KC and HSC in the CD38-dependent interactions of NAD+ with INH, leading to the formation of both INH-NAD and AcINH-NAD in the liver. NAD CD38 antigen Mus musculus