Title : c-Abl Tyrosine Kinase Is Regulated Downstream of the Cytoskeletal Protein Synemin in Head and Neck Squamous Cell Carcinoma Radioresistance and DNA Repair.

Pub. Date : 2020 Oct 1

PMID : 33019757






1 Functional Relationships(s)
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1 Upon irradiation and synemin inhibition, c-Abl hyperphosphorylation on tyrosine (Y) 412 and threonine (T) 735 was significantly reduced, prompting us to hypothesize that c-Abl tyrosine kinase is an important signaling component of the synemin-mediated radioresistance pathway. Tyrosine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens