Title : Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes in rats by inhibition of PKCĪ²/p66Shc axis and activation of FOXO-3a.

Pub. Date : 2021 Jan

PMID : 33017608






3 Functional Relationships(s)
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1 In the kidneys of both control and diabetic rats, Curcumin reduced the levels of reactive oxygen species (ROS), increased mRNA levels of manganese superoxide dismutase (MnSOD) and gamma-glutamyl ligase (GCL-c), increased glutathione (GSH) and protein levels of Bcl-2 and MnSOD, and increased the nuclear levels of nuclear factor2 (Nrf2) and FOXO-3a. Curcumin superoxide dismutase 2 Rattus norvegicus
2 In the kidneys of both control and diabetic rats, Curcumin reduced the levels of reactive oxygen species (ROS), increased mRNA levels of manganese superoxide dismutase (MnSOD) and gamma-glutamyl ligase (GCL-c), increased glutathione (GSH) and protein levels of Bcl-2 and MnSOD, and increased the nuclear levels of nuclear factor2 (Nrf2) and FOXO-3a. Curcumin superoxide dismutase 2 Rattus norvegicus
3 In the kidneys of both control and diabetic rats, Curcumin reduced the levels of reactive oxygen species (ROS), increased mRNA levels of manganese superoxide dismutase (MnSOD) and gamma-glutamyl ligase (GCL-c), increased glutathione (GSH) and protein levels of Bcl-2 and MnSOD, and increased the nuclear levels of nuclear factor2 (Nrf2) and FOXO-3a. Curcumin superoxide dismutase 2 Rattus norvegicus