Title : Mutual Antagonism of Hypoxia-Inducible Factor Isoforms in Cardiac, Vascular, and Renal Disorders.

Pub. Date : 2020 Sep

PMID : 33015417






1 Functional Relationships(s)
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1 Selective activation of HIF-2alpha can be achieved with drugs that: 1) inhibit isoform-selective prolyl hydroxylases (e.g., cobalt chloride and roxadustat); or 2) promote the actions of the redox sensor, sirtuin-1 (e.g., sodium-glucose cotransporter 2 inhibitors). roxadustat endothelial PAS domain protein 1 Homo sapiens