Pub. Date : 2020
PMID : 33014814
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin Overcomes Acquired Resistance to EGFR TKIs in EGFR-Mutant Lung Cancer via AMPK/ERK/NF-kappaB Signaling Pathway. | Metformin | epidermal growth factor receptor | Homo sapiens |
| 2 | Metformin Overcomes Acquired Resistance to EGFR TKIs in EGFR-Mutant Lung Cancer via AMPK/ERK/NF-kappaB Signaling Pathway. | Metformin | epidermal growth factor receptor | Homo sapiens |
| 3 | Metformin inhibited proliferation and promoted apoptosis of lung cancer cells, especially those with acquired EGFR TKI resistance. | Metformin | epidermal growth factor receptor | Homo sapiens |
| 4 | Moreover, metformin reversed and delayed acquired resistance to EGFR TKIs as well as suppressed cancer stemness in EGFR-mutant lung cancer. | Metformin | epidermal growth factor receptor | Homo sapiens |
| 5 | Moreover, metformin reversed and delayed acquired resistance to EGFR TKIs as well as suppressed cancer stemness in EGFR-mutant lung cancer. | Metformin | epidermal growth factor receptor | Homo sapiens |
| 6 | Conclusions: Our data provided novel and further molecular rationale and preclinical data to support combination of metformin with EGFR TKIs to treat EGFR-mutant lung cancer patients, especially those with acquired resistance. | Metformin | epidermal growth factor receptor | Homo sapiens |