Title : Pharmacological Inhibition of Amyloidogenic APP Processing and Knock-Down of APP in Primary Human Macrophages Impairs the Secretion of Cytokines.

Pub. Date : 2020

PMID : 33013850






1 Functional Relationships(s)
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1 We inhibited the secretion of Abeta peptides in primary human monocyte derived macrophages with the gamma-secretase inhibitor N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine-t-butyl-ester (DAPT) or the beta-secretase inhibitor GL-189. dapt amyloid beta precursor protein Homo sapiens