Title : In Mixed Lymphocyte Reaction, the Hypoxia-Inducible Factor Prolyl-Hydroxylase Inhibitor Roxadustat Suppresses Cellular and Humoral Alloimmunity.

Pub. Date : 2020 Oct 4

PMID : 33011826






1 Functional Relationships(s)
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Compound Name
Protein Name
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1 Roxadustat stabilized HIF-1alpha and HIF-2alpha, suppressed cell proliferation, inhibited CD4+ T-cell differentiation into Th1 and Th17 subsets, while it favored differentiation towards Th2, Treg and Tfh. roxadustat endothelial PAS domain protein 1 Homo sapiens