Title : sPLA2-IIa participates in ocular surface inflammation in humans with dry eye disease.

Pub. Date : 2020 Dec

PMID : 33011237






2 Functional Relationships(s)
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Protein Name
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1 Single treatment of sPLA2-IIa, IL-1beta or TNF-alpha of HCjE cells induced minimal to no PGE2 production. Dinoprostone interleukin 1 alpha Homo sapiens
2 When sPLA2-IIa was added to HCjE cells that were pre-treated with pro-inflammatory cytokines (TNF-alpha or IL-1beta), significant stimulation of PGE2 production was observed, concurrent with the extensive transcriptional changes of many inflammatory cytokines/chemokines and their receptors. Dinoprostone interleukin 1 alpha Homo sapiens