Pub. Date : 2021 Jan
PMID : 33007707
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-kappaB pathway. | Epirubicin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | BACKGROUND: Epirubicin is a first-line chemotherapeutic drug for the clinical treatment of diffuse large B cell lymphoma (DLBCL), but the overexpression of multidrug resistance (MDR) transporter proteins, especially P-glycoprotein (P-gp), renders epirubicin ineffective. | Epirubicin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | BACKGROUND: Epirubicin is a first-line chemotherapeutic drug for the clinical treatment of diffuse large B cell lymphoma (DLBCL), but the overexpression of multidrug resistance (MDR) transporter proteins, especially P-glycoprotein (P-gp), renders epirubicin ineffective. | Epirubicin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Further, melatonin synergized with epirubicin to promote the activation of the mitochondria-mediated apoptosis pathway and increased the accumulation of epirubicin in DLBCL cells by inhibiting the expression and function of P-gp. | Epirubicin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Epirubicin was subsequently discovered to upregulate the expression of P-gp by activating the NF-kappaB pathway in the DLBCL cells. | Epirubicin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | CONCLUSIONS: Our results demonstrated that melatonin inactivates the NF-kappaB pathway and downregulates the expression of P-gp, ultimately sensitizing DLBCL cells to the epirubicin that suppresses their growth. | Epirubicin | ATP binding cassette subfamily B member 1 | Homo sapiens |