Pub. Date : 2020 Nov
PMID : 33000204
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | KCNQ1OT1 contributes to sorafenib resistance and programmed death-ligand-1-mediated immune escape via sponging miR-506 in hepatocellular carcinoma cells. | Sorafenib | microRNA 506 | Homo sapiens |
| 2 | KCNQ1OT1 and PD-L1 were found to be upregulated and miR-506 was downregulated in sorafenib-resistant HCC tissues and cells. | Sorafenib | microRNA 506 | Homo sapiens |
| 3 | In addition, it was demonstrated that KCNQ1OT1 functioned as a competing endogenous RNA of miR-506 and increased PD-L1 expression in sorafenib-resistant HCC cells. | Sorafenib | microRNA 506 | Homo sapiens |
| 4 | miR-506 inhibition abolished the effects of KCNQ1OT1 knockdown on sorafenib sensitivity, tumor growth, the tumor microenvironment and T-cell apoptosis. | Sorafenib | microRNA 506 | Homo sapiens |
| 5 | In conclusion, KCNQ1OT1 knockdown inhibited sorafenib resistance and PD-L1-mediated immune escape by sponging miR-506 in sorafenib-resistant HCC cells. | Sorafenib | microRNA 506 | Homo sapiens |