PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33000204-0 2020 KCNQ1OT1 contributes to sorafenib resistance and programmed death-ligand-1-mediated immune escape via sponging miR-506 in hepatocellular carcinoma cells. Sorafenib 24-33 microRNA 506 Homo sapiens 111-118 33000204-8 2020 KCNQ1OT1 and PD-L1 were found to be upregulated and miR-506 was downregulated in sorafenib-resistant HCC tissues and cells. Sorafenib 81-90 microRNA 506 Homo sapiens 52-59 33000204-11 2020 In addition, it was demonstrated that KCNQ1OT1 functioned as a competing endogenous RNA of miR-506 and increased PD-L1 expression in sorafenib-resistant HCC cells. Sorafenib 133-142 microRNA 506 Homo sapiens 91-98 33000204-12 2020 miR-506 inhibition abolished the effects of KCNQ1OT1 knockdown on sorafenib sensitivity, tumor growth, the tumor microenvironment and T-cell apoptosis. Sorafenib 66-75 microRNA 506 Homo sapiens 0-7 33000204-13 2020 In conclusion, KCNQ1OT1 knockdown inhibited sorafenib resistance and PD-L1-mediated immune escape by sponging miR-506 in sorafenib-resistant HCC cells. Sorafenib 121-130 microRNA 506 Homo sapiens 110-117