Title : Osteoclast Differentiation Is Suppressed by Increased O-GlcNAcylation Due to Thiamet G Treatment.

Pub. Date : 2020

PMID : 32999159






2 Functional Relationships(s)
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1 Thiamet G treatment increased global O-GlcNAcylation in murine RAW264 cells and suppressed receptor activator of nuclear factor-kappaB ligand (RANKL)-dependent formation in tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cells, thereby suppressing the upregulation of osteoclast specific genes. thiamet G tumor necrosis factor (ligand) superfamily, member 11 Mus musculus
2 Thiamet G treatment also suppressed RANKL and macrophage colony-stimulating factor (M-CSF) dependent osteoclast formation and bone-resorbing activity in mouse primary bone marrow cells and human peripheral blood mononuclear cells. thiamet G tumor necrosis factor (ligand) superfamily, member 11 Mus musculus