Pub. Date : 2020 Sep 25
PMID : 32992777
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | (3) Results: Hydroxychloroquine did not inhibit BCRP or the OATPs tested but inhibited P-gp at concentrations exceeding 10 microM. | Hydroxychloroquine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | P-gp overexpressing cells were 5.2-fold more resistant to hydroxychloroquine than control cells stressing its substrate characteristics. | Hydroxychloroquine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | (4) Conclusions: This is the first evidence that hydroxychloroquine"s interaction potential with drug transporters is low, albeit bioavailability of simultaneously orally administered P-gp substrates might be increased by hydroxychloroquine. | Hydroxychloroquine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | (4) Conclusions: This is the first evidence that hydroxychloroquine"s interaction potential with drug transporters is low, albeit bioavailability of simultaneously orally administered P-gp substrates might be increased by hydroxychloroquine. | Hydroxychloroquine | ATP binding cassette subfamily B member 1 | Homo sapiens |