Title : Ursolic Acid Protects Against Proliferation and Inflammatory Response in LPS-Treated Gastric Tumour Model and Cells by Inhibiting NLRP3 Inflammasome Activation.

Pub. Date : 2020

PMID : 32982435






3 Functional Relationships(s)
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1 This study also aimed to confirm whether ursolic acid can protect against proliferation and the inflammatory response induced by LPS, by inhibiting the activation of the NLRP3 inflammasome via the NF-kappaB pathway. ursolic acid nuclear factor kappa B subunit 1 Homo sapiens
2 In addition, ursolic acid inhibited the LPS-induced activation of NF-kappaB. ursolic acid nuclear factor kappa B subunit 1 Homo sapiens
3 Conclusion: In conclusion, these results demonstrated that ursolic acid could suppress proliferation and the inflammatory response in an LPS-induced mouse gastric tumour model and human BGC-823 cells by inhibiting the activation of the NLRP3 inflammasome via the NF-kappaB pathway. ursolic acid nuclear factor kappa B subunit 1 Homo sapiens