Title : Development of diarylpentadienone analogues as alpha-glucosidase inhibitor: Synthesis, in vitro biological and in vivo toxicity evaluations, and molecular docking analysis.

Pub. Date : 2020 Nov

PMID : 32971414






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1 A series of aminated- (1-9) and sulfonamide-containing diarylpentadienones (10-18) were synthesized, structurally characterized, and evaluated for their in vitro anti-diabetic potential on alpha-glucosidase and DPP-4 enzymes. diarylpentadienones dipeptidyl peptidase 4 Homo sapiens