Title : Beneficial Effects of Glycyrrhizin in Chronic Periodontitis Through the Inhibition of Inflammatory Response.

Pub. Date : 2020 Jul-Sep

PMID : 32963505






2 Functional Relationships(s)
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1 TNF-alpha-treated human periodontal ligament stem cell (hPDLSC) model was established, and was administrated with 1, 2 or 5 mM glycyrrhizin for 24 h. After treatment, the expression of HMGB1and inflammatory cytokines was monitored. Glycyrrhizic Acid high mobility group box 1 Homo sapiens
2 Glycyrrhizin significantly prevented TNF-alpha-induced expression of HMGB1 (691.5 +- 136.4 vs 142.8 +- 57.3 pg/mL), IL-6 (388.1 +- 85.2 vs 189.4 +- 61.2 pg/mL) and IL-1beta (176.3 +- 47.2 vs 53.9 +- 25.7 pg/mL) in hPDLSC. Glycyrrhizic Acid high mobility group box 1 Homo sapiens