Title : Decreased AMP-activated protein kinase (AMPK) function and protective effect of metformin in neonatal rat pups exposed to hyperoxia lung injury.

Pub. Date : 2020 Sep

PMID : 32959498






2 Functional Relationships(s)
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1 Metformin increased the levels of p-AMPK and PGC-1alpha, a downstream AMPK target which regulates mitochondrial biogenesis, at P4, P10, and P21 in hyperoxia pups. Metformin KRAS proto-oncogene, GTPase Rattus norvegicus
2 Radial alveolar count and alveolar septal tips were decreased and mean linear intercept increased in hyperoxia-exposed pups at P10 and the changes persisted at P21; these were improved by metformin. Metformin KRAS proto-oncogene, GTPase Rattus norvegicus