Protein Name KRAS proto-oncogene, GTPase
Organism Rattus norvegicus
Gene ID 24525
Gene Symbol

Kras

UniProt P08644 (RASK_RAT), A0JN17 (A0JN17_RAT)
Relationships Total Number of functionally related compound(s) : 564
Total Number of Articles : 670
Description

KRAS proto-oncogene, GTPase

Gene Summary

Enables GDP binding activity; GMP binding activity; and LRR domain binding activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of cellular senescence; and response to corticosteroid. Located in membrane raft and mitochondrion. Used to study bronchiolo-alveolar adenocarcinoma; endometrial adenocarcinoma; hepatocellular adenoma; hepatocellular carcinoma; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • GTPase KRas
  • K-Ras 2
  • Kirsten rat sarcoma viral oncogene homolog
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Properties