Pub. Date : 2020 Nov 27
PMID : 32958515
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The highest-ranked drug was the macrolide antibiotic Clarithromycin, which has previously been reported to have anti-inflammatory effects in aseptic conditions.Clarithromycin"s effects were validated in several experiments: it influenced NF-kappaB mediated transcription in murine peritoneal macrophages and intestinal enteroids; it suppressed NF-kappaB protein shuttling in murine reporter enteroids; it suppressed NF-kappaB (p65) DNA binding in the small intestine of mice exposed to LPS, and it reduced the severity of dextran sulphate sodium-induced colitis in C57BL/6 mice. | dextran sulphate sodium | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |