Pub. Date : 2020 Sep 17
PMID : 32957649
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Low-Dose Nicotine Activates EGFR Signaling via alpha5-nAChR and Promotes Lung Adenocarcinoma Progression. | Nicotine | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |
| 2 | In LAC cell lines alpha 5-nAChR interacts with epidermal growth factor receptor (EGFR), positively regulates EGFR pathway, enhances the expression of epithelial-mesenchymal transition markers, and is essential for low-dose nicotine-induced EGFR phosphorylation. | Nicotine | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |
| 3 | Functionally, low-dose nicotine requires alpha 5-nAChR to enhance cell migration, invasion, and proliferation. | Nicotine | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |
| 4 | Our data identified alpha 5-nAChR as an essential mediator for low-dose nicotine-dependent LAC progression possibly through signaling crosstalk with EGFR, supporting the involvement of environmental smoke in tumor progression in LAC patients. | Nicotine | cholinergic receptor nicotinic alpha 4 subunit | Homo sapiens |