Title : All-trans retinoic acid increases ARPE-19 cell apoptosis via activation of reactive oxygen species and endoplasmic reticulum stress pathways.

Pub. Date : 2020

PMID : 32953569






2 Functional Relationships(s)
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1 Western blot and qRT-PCR revealed that levels of CHOP and BIP were elevated in a concentration-dependent pattern after the cells were incubated with ATRA (2.5-20 micromol/L). Tretinoin DNA damage inducible transcript 3 Homo sapiens
2 The upregulation of VEGF-A and CHOP induced by ATRA could be inhibited by NAC (antioxidant) and Salubrinal (ERS inhibitor) in vitro. Tretinoin DNA damage inducible transcript 3 Homo sapiens