Title : Coupling of HSP72 α-Helix Subdomains by the Unexpected Irreversible Targeting of Lysine-56 over Cysteine-17; Coevolution of Covalent Bonding.

Pub. Date : 2020 Sep 16

PMID : 32947765






1 Functional Relationships(s)
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1 The closed conformation maintained the crucial salt-bridge between Glu-268 and Lys-56 residues, which strengthens the interaction affinity of the inhibitor nearly identical to adenosine triphosphate (ADP/Pi) bound to the HSP72-NBD. Adenosine Diphosphate heat shock protein family A (Hsp70) member 1A Homo sapiens