Pub. Date : 2020 Sep 28
PMID : 32942936
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Proteins involved in nuclear factor kappa B (NF-kappaB) signaling pathway and NOD-like receptor protein 3 (NLRP3) inflammasome were analyzed by Western blotting.Results: Alcohol exposure dramatically upregulated ROCK2 expression and lactate dehydrogenase (LDH) activity in astrocytes. | Alcohols | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Proteins involved in nuclear factor kappa B (NF-kappaB) signaling pathway and NOD-like receptor protein 3 (NLRP3) inflammasome were analyzed by Western blotting.Results: Alcohol exposure dramatically upregulated ROCK2 expression and lactate dehydrogenase (LDH) activity in astrocytes. | Alcohols | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | More importantly, downregulation of ROCK2 inhibited the activation of NF-kappaB signaling pathway and NLRP3 inflammasome.Conclusion: Therefore, ROCK2 could be a potential target to treat alcohol-induced astrocytic injury and the downregulation of ROCK2 might be a promising approach to protect against alcohol-induced astrocytic injury. | Alcohols | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | More importantly, downregulation of ROCK2 inhibited the activation of NF-kappaB signaling pathway and NLRP3 inflammasome.Conclusion: Therefore, ROCK2 could be a potential target to treat alcohol-induced astrocytic injury and the downregulation of ROCK2 might be a promising approach to protect against alcohol-induced astrocytic injury. | Alcohols | nuclear factor kappa B subunit 1 | Homo sapiens |