Title : Chloroquine Sensitizes GNAQ/11-mutated Melanoma to MEK1/2 Inhibition.

Pub. Date : 2020 Dec 1

PMID : 32933997






1 Functional Relationships(s)
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1 CONCLUSIONS: These results suggest that YAP, MEK1/2, and lysosome function are necessary and critical targets for the therapy of GNAQ/11-driven melanoma, and identify trametinib plus hydroxychloroquine as a potential treatment strategy for metastatic uveal melanoma. Hydroxychloroquine Yes1 associated transcriptional regulator Homo sapiens