Title : Minor Ginsenoside Rg2 and Rh1 Attenuates LPS-Induced Acute Liver and Kidney Damages via Downregulating Activation of TLR4-STAT1 and Inflammatory Cytokine Production in Macrophages.

Pub. Date : 2020 Sep 11

PMID : 32932915






5 Functional Relationships(s)
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1 Minor Ginsenoside Rg2 and Rh1 Attenuates LPS-Induced Acute Liver and Kidney Damages via Downregulating Activation of TLR4-STAT1 and Inflammatory Cytokine Production in Macrophages. 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone toll-like receptor 4 Mus musculus
2 Moreover, Rg2 and Rh1 combination treatment inhibited the binding of LPS to toll-like receptor 4 (TLR4) on peritoneal macrophages. 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone toll-like receptor 4 Mus musculus
3 Moreover, Rg2 and Rh1 combination treatment inhibited the binding of LPS to toll-like receptor 4 (TLR4) on peritoneal macrophages. 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone toll-like receptor 4 Mus musculus
4 Therefore, the combination of ginsenoside Rg2 and Rh1 suppressed inflammation by abolishing the binding of LPS to TLR4, thereby inhibiting the TLR4-mediated signaling pathway. 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone toll-like receptor 4 Mus musculus
5 Therefore, the combination of ginsenoside Rg2 and Rh1 suppressed inflammation by abolishing the binding of LPS to TLR4, thereby inhibiting the TLR4-mediated signaling pathway. 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone toll-like receptor 4 Mus musculus