Title : Deficiency in the function of inhibitory interneurons contributes to glutamate-associated central sensitization through GABABR2-SynCAM1 signaling in chronic migraine rats.

Pub. Date : 2020 Nov

PMID : 32931071






2 Functional Relationships(s)
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1 Afterward, the application of Baclofen and H89 alleviated the IS-evoked hyperalgesia and extenuated vesicular glutamate transporter 2 (VGLUT2), glutamate, calcitonin gene-related peptide (CGRP), and c-Fos expression by regulating the GABABR2/PKA/SynCAM1 pathway in the PAG of CM rats, while the application of CGP35348 and 8-Bromo-cAMP exactly exerted the opposite effect. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide calcitonin-related polypeptide alpha Rattus norvegicus
2 Afterward, the application of Baclofen and H89 alleviated the IS-evoked hyperalgesia and extenuated vesicular glutamate transporter 2 (VGLUT2), glutamate, calcitonin gene-related peptide (CGRP), and c-Fos expression by regulating the GABABR2/PKA/SynCAM1 pathway in the PAG of CM rats, while the application of CGP35348 and 8-Bromo-cAMP exactly exerted the opposite effect. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide calcitonin-related polypeptide alpha Rattus norvegicus